Masterveranstaltungen

(Kurse sind auf Englisch)

Advances in Radiation and Medical Physics

The term "Medical Physics" includes especially clinical work and responsibilities. It contains many different areas such as Radiation Protection in official institutions, maintenance of all parts/devices/machines that produce ionizing radiation as well as radiation treatment planning and monitoring. With regards to this broad subject, the course covers standard and advanced methods in the following main topics.

Content:

Refreshing Medical Physics and radiation protection
Dosimetry
Numerical dosimetry - Biokinetics
Numerical dosimetry - Monte Carlo Simulations
Radiation Therapy Monitoring
HIFU therapy
Breath gas analysis
Audiology Summary / new directions in medical physics e.g. AI applications

Time:

WiSe Lecture

SoSe Lab

Basics of Medical Image Science

The student will:

Get an overview about radiation principles including types of ionizing radiation and their behaviour
Learn about the difference between active and passive imaging methods and examples from medical imaging techniques
Get to know system theory of medical imaging systems
Learn to understand the differences between Fourier-based and task-based image quality descriptions
understand how image quality can be described by different types of observers (human and model observers)

Content:

Radiation physics for alpha-, beta-, gamma-, neutron- and X-ray radiation
MTF, NPS and DQE
Ideal observer, human observer models, ROC curves

Time:

SoSe

Nuclear Medicine

The students will learn about the fundamentals of physics and technology used in nuclear medicine. The course will cover the basics of radioactive processes and materials. It will then describe the various applications for diagnostic and therapeutic applications, its measurements, specific radiation protection measures and current developments including theranostics.

Content:

Introduction - what is nuclear medicine?
The basic elements of matter
The nucleus
Decay processes
Radiation therapy with radioisotopes
Brief overview on medical imaging with radioisotopes
Tracers
Specific tasks for radiation protection
Prospects including theranostics

Time:

SoSe

Pharmacokinetic and Pharmacodynamic Modeling

The students will learn how to derive pharmacokinetic compartment models including various drugs and administration routes on different complexity scales. Additionally, fundamental knowledge of mass balances, transport phenomena and numerical simulation methods will be illustrated. The derived models will be implemented in MATLAB and the model predictions analyzed and discussed.

Content:

Introduction into pharmacokinetic and pharmacodynamic modeling
Pharmacokinetic and pharmacodynamic parameters
Fundamentals for modeling biological and medical systems
Constitutive equations and transport phenomena
Numerical methods for solving differential equations
Methods for optimal experimental design

Time:

SoSe

Planar Medical Imaging Techniques

The course gives an introduction to planar medical imaging technologies. Beside projectional radiography other relevant planar imaging techniques are presented. For every imaging technique we will go quickly into the image acquisition and processing and look at the key technologies that are needed to realize the individual imaging setups.

Content:

X-ray projection radiography
- Absorption
- Dark field
- Phase contrast
Optical imaging
- Microscopy
- Infrared
- Coherence
Ultrasound and impedance imaging
- Examples for molecular imaging
- Magnetic nanoparticle imaging
- Scintigraphy

Time:

WiSe

Scientific Working

The skills that are essential when working as part of scientific team are collaboration with other team members, presenting results of the work and evaluation of the work of others. This course aims to strengthen these skills in the students and prepare them for active collaboration on further scientific projects.

Content:

Prepare 20 min presentation based on the per-reviewed scientific paper from reputable journal.
Prepare video with his/her delivery of the presentation.
Review presentations of 2 other people.
Respond to the reviewers regarding his/her own presentation.
Deliver the presentation/prepare final video.
Evaluate final presentation of two other students

Time:

SoSe

WiSe (repetition course)

Principles in clinical trials, market introduction and market surveillance of medical devices

In contrast to pharmaceuticals, no worldwide uniform legally requirements are available for the approval and CE certification of medical devices. Every manufacturer is responsible to set up the process and documentation of his medical devices to get it approved according to defines OECD Guidelines and ISO norms. The regulatory affair offers an unexpectedly exciting and diverse range of tasks for all students, especially in small and medium-sized companies. As part of the compulsory elective module, we want to deepen topics from the field of clinical studies as well as market introduction and market surveillance in this module.

Content:

The content is based on the specifications for the European CE approval and relevant DIN ISO specification. It includes following basics of the pre-market phase: Risk management and assessment, risk-benefit analysis, regulatory affairs manager, technical documentation, quality management, PDCA cycle, patient safety vs. Customer satisfaction, clinical evaluation and proof of effectiveness. After the lectures, different international admission procedures in the USA, Russia, Brazil, Japan, ASEAN, Canada, China, India, Saudi Arabia and Mexico will be examined. Therefor we will build groups of two students to perform a Term work. Content of work are selected examples to illuminate the approval procedures for different medical device classes and to address particular regulatory issues. These Term work are presented and discussed in a short lecture to all students. The homework is 50% of the examination performance. In addition, an exam is written at the end of the course, which also accounts for 50% of the total grade.

Time:

WiSe

Imaging and Visualization in Biomedical Engineering

Content:

Imaging methods in 2D and 3D, including various methods like CT, dual energy and spectral X-ray absorption, phase contrast imaging, fluorescence imaging, nanoparticle imaging, Nuclear medical imaging basics, MRI, Ultrasound imaging, Microscopy

Time:

WiSe

Introduction to Programming Techniques in Engineering

Content:

Fundamentals of Python programming
Data manipulation and representation
Scientific calculations
Interactive graphical user interface (GUI)
Arduino programming platform
Arduino hardware development

Time:

WiSe

Solution Design in Medical Engineering

Content:

Students will propose, work and present a medical engineering related design project in a small group. The projects are thematic for each semester. With the support from the lecturer, the students will learn how to manage their project and their fellow teammates. They will do prototyping and debugging in a team. They will document their journey and learning experience in a website or blog. The final presentation includes live demonstration of their project.

Time:

WiSe